1. Shoemaker LN, Kamar F, Milej D, Fitzgibbon-Collins L, Eskandari R, Bhangu J, Shoemaker JK, St Lawrence K. Two paths to one destination: Altered low-frequency oscillations of cerebral perfusion and oxygenation but not oxygen metabolism in mild cognitive impairment. J Appl Physiol (1985). 2025 Apr 15. doi: 10.1152/japplphysiol.00884.2024. Epub ahead of print. PMID: 40234388.
2. Shoemaker LN, Matern T, Kamar F, St Lawrence K, Ortega-Gutierrez S, Zanaty M, Shoemaker JK. Blood pressure in human large cerebral arteries: A feasibility study. J Appl Physiol (1985). 2025 Mar 1;138(3):693-698. doi: 10.1152/japplphysiol.00825.2024. Epub 2025 Feb 7. PMID: 39918464.
Featured on the issue cover:
1. Shoemaker LN, Samaei S, Deller G, Wang DJJ, Milej D, St Lawrence K. All-optics technique for monitoring absolute cerebral blood flow: validation against magnetic resonance imaging perfusion. Neurophotonics. 2024 Oct;11(4):045002. doi: 10.1117/1.NPh.11.4.045002. Epub 2024 Oct 3. PMID: 39372121; PMCID: PMC11448701.
2. Kamar F, Shoemaker LN, Eskandari R, Milej D, Drosdowech D, Murkin JM, St Lawrence K, Chui J, Diop M. Assessing changes in regional cerebral hemodynamics in adults with a high-density full-head coverage time-resolved near-infrared spectroscopy device. J Biomed Opt. 2024 Jun;29(Suppl 3):S33302. doi: 10.1117/1.JBO.29.S3.S33302. Epub 2024 May 3. PubMed PMID: 38707651; PubMed Central PMCID: PMC11068267.
3. Corsaut J, Soto E, Biernaski H, Kovacs MS, St Lawrence K, Hicks JW. Frugal and Translatable [(15)O]O(2) Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR. Diagnostics (Basel). 2024 Apr 25;14(9). doi: 10.3390/diagnostics14090902. PubMed PMID: 38732316; PubMed Central PMCID: PMC11083888.
4. Tang L, Kebaya LMN, Altamimi T, Kowalczyk A, Musabi M, Roychaudhuri S, Vahidi H, Meyerink P, de Ribaupierre S, Bhattacharya S, de Moraes LTAR, St Lawrence K, Duerden EG. Altered resting-state functional connectivity in newborns with hypoxic ischemic encephalopathy assessed using high-density functional near-infrared spectroscopy. Sci Rep. 2024 Feb 7;14(1):3176. doi: 10.1038/s41598-024-53256-0. PubMed PMID: 38326455; PubMed Central PMCID: PMC10850364.
Khaw AV, Thiessen JD, St Lawrence K, Pandey SK. The Quest of Characterizing Hemodynamic Failure in Patients With Cerebrovascular Disease. J Am Heart Assoc. 2023 Dec 19;12(24):e032657. doi: 10.1161/JAHA.123.032657. Epub 2023 Dec 12. PubMed PMID: 38084748; PubMed Central PMCID: PMC10863759.
Shoemaker LN, Milej D, Mistry J, St Lawrence K. Using depth-enhanced diffuse correlation spectroscopy and near-infrared spectroscopy to isolate cerebral hemodynamics during transient hypotension. Neurophotonics. 2023 Apr;10(2):025013. doi: 10.1117/1.NPh.10.2.025013. Epub 2023 Jun 5. PubMed PMID: 37284246; PubMed Central PMCID: PMC10241370.
Shao X, Zhao C, Shou Q, St Lawrence KS, Wang DJJ. Quantification of blood-brain barrier water exchange and permeability with multidelay diffusion-weighted pseudo-continuous arterial spin labeling. Magn Reson Med. 2023 May;89(5):1990-2004. doi: 10.1002/mrm.29581. Epub 2023 Jan 9. PubMed PMID: 36622951; PubMed Central PMCID: PMC10079266.
Dassanayake P, Anazodo UC, Liu L, Narciso L, Iacobelli M, Hicks J, Rusjan P, Finger E, St Lawrence K. Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [(18)F]FEPPA positron emission tomography. EJNMMI Res. 2023 Jan 12;13(1):1. doi: 10.1186/s13550-023-00950-1. PubMed PMID: 36633702; PubMed Central PMCID: PMC9837356.
Ali S, Altamimi T, Annink K, Bartmann P, Beato N, Belker K, Ben-David D, Benders M, Bhattacharya S, Anbu Chakkarapani A, Anbu Chakkarapani A, Charbonneau L, Cherkerzian S, Chowdhury RA, Christou H, de Ribaupierre D, Dehaes M, Domogalla C, Duerden EG, El-Dib M, Elanbari M, Elshibiny H, Engel C, Felderhoff U, Flemmer AW, Franceschini MA, Franz A, Garvey A, Groenendaal F, Gupta S, Hannon K, Hellström-Westas L, Herber-Jonat S, Holz S, Hüning B, Inder T, Jamil A, Jilson T, Kebaya LMN, Keller M, Khalifa AKM, Kim SH, Kittel J, Koch L, Kowalczyk A, Kühr J, St Lawrence K, Lee S, Marandyuk B, Marlow N, Mayorga PC, Meyer R, Meyerink P, Miró J, More K, Munk A, Munster C, Musabi M, Nuyt AM, Peters J, Plum A, Poirier N, Pöschl J, Raboisson MJ, Robinson J, Roychaudhuri S, Rüdiger M, Sarközy G, Saugstad OD, Segerer H, Soni N, Stein A, Steins-Rang C, Sunwoo J, Szakmar E, Tang L, Taskin E, Vahidi H, Waldherr S, Wieg C, Winkler S, Wu R, Yajamanyam PK, Yapicioglu-Yildizdas H. Proceedings of the 14th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc. J Neonatal Perinatal Med. 2023;16(s1):S63-S73. doi: 10.3233/NPM-239004. PubMed PMID: 37599543.
Narciso L, Ssali T, Liu L, Jesso S, Hicks JW, Anazodo U, Finger E, St Lawrence K. Noninvasive Quantification of Cerebral Blood Flow Using Hybrid PET/MR Imaging to Extract the [(15) O]H(2) O Image-Derived Input Function Free of Partial Volume Errors. J Magn Reson Imaging. 2022 Oct;56(4):1243-1255. doi: 10.1002/jmri.28134. Epub 2022 Feb 28. PubMed PMID: 35226390.
Dassanayake P, Cui L, Finger E, Kewin M, Hadaway J, Soddu A, Jakoby B, Zuehlsdorf S, Lawrence KSS, Moran G, Anazodo UC. caliPER: A software for blood-free parametric Patlak mapping using PET/MRI input function. Neuroimage. 2022 Aug 1;256:119261. doi: 10.1016/j.neuroimage.2022.119261. Epub 2022 Apr 29. PubMed PMID: 35500806.
Ssali T, Narciso L, Hicks J, Liu L, Jesso S, Richardson L, Günther M, Konstandin S, Eickel K, Prato F, Anazodo UC, Finger E, St Lawrence K. Concordance of regional hypoperfusion by pCASL MRI and (15)O-water PET in frontotemporal dementia: Is pCASL an efficacious alternative?. Neuroimage Clin. 2022;33:102950. doi: 10.1016/j.nicl.2022.102950. Epub 2022 Jan 31. PubMed PMID: 35134705; PubMed Central PMCID: PMC8829802.
Rajaram A, Milej D, Suwalski M, Kebaya L, Kewin M, Yip L, de Ribaupierre S, Han V, Diop M, Bhattacharya S, St Lawrence K. Assessing cerebral blood flow, oxygenation and cytochrome c oxidase stability in preterm infants during the first 3 days after birth. Sci Rep. 2022 Jan 7;12(1):181. doi: 10.1038/s41598-021-03830-7. PubMed PMID: 34996949; PubMed Central PMCID: PMC8741949.
Ssali T, Anazodo UC, Narciso L, Liu L, Jesso S, Richardson L, Günther M, Konstandin S, Eickel K, Prato F, Finger E, St Lawrence K. Sensitivity of Arterial Spin Labeling for Characterization of Longitudinal Perfusion Changes in Frontotemporal Dementia and Related Disorders. Neuroimage Clin. 2022;35:102853. doi: 10.1016/j.nicl.2021.102853. Epub 2021 Oct 7. PubMed PMID: 34697009; PubMed Central PMCID: PMC9421452.
Huang SS, Pavenski K, Lee TY, Jurkiewicz MT, Bharatha A, Thiessen JD, St Lawrence K, Théberge J, Mandzia J, Barth D, Licht C, Patriquin CJ. Blood-brain barrier permeability in survivors of immune-mediated thrombotic thrombocytopenic purpura: a pilot study. Blood Adv. 2021 Oct 26;5(20):4211-4218. doi: 10.1182/bloodadvances.2021005317. PubMed PMID: 34521110; PubMed Central PMCID: PMC8945621.
Narciso L, Ssali T, Liu L, Biernaski H, Butler J, Morrison L, Hadway J, Corsaut J, Hicks JW, Langham MC, Wehrli FW, Iida H, St Lawrence K. A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model. J Nucl Med. 2021 Mar 19;62(12):1789-96. doi: 10.2967/jnumed.120.260521. [Epub ahead of print] PubMed PMID: 33741647; PubMed Central PMCID: PMC8612192.
Narciso L, Ssali T, Iida H, St Lawrence K. A non-invasive reference-based method for imaging the cerebral metabolic rate of oxygen by PET/MR: theory and error analysis. Phys Med Biol. 2021 Mar 4;66(6):065009. doi: 10.1088/1361-6560/abe737. PubMed PMID: 33596555.
McManus R, Ioussoufovitch S, Froats E, St Lawrence K, Van Uum S, Diop M. Dynamic response of cerebral blood flow to insulin-induced hypoglycemia. Sci Rep. 2020 Dec 4;10(1):21300. doi: 10.1038/s41598-020-77626-6. PubMed PMID: 33277531; PubMed Central PMCID: PMC7718270.
Milej D, Abdalmalak A, Rajaram A, St Lawrence K. Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism. Neurophotonics. 2020 Oct;7(4):045002. doi: 10.1117/1.NPh.7.4.045002. Epub 2020 Oct 7. PubMed PMID: 33062801; PubMed Central PMCID: PMC7540337.
Rajaram A, Milej D, Suwalski M, Yip LCM, Guo LR, Chu MWA, Chui J, Diop M, Murkin JM, St Lawrence K. Optical monitoring of cerebral perfusion and metabolism in adults during cardiac surgery with cardiopulmonary bypass. Biomed Opt Express. 2020 Oct 1;11(10):5967-5981. doi: 10.1364/BOE.404101. eCollection 2020 Oct 1. PubMed PMID: 33149999; PubMed Central PMCID: PMC7587277.
Cockburn N, Corsaut J, Kovacs MS, St Lawrence K, Hicks JW. Validation protocol for current good manufacturing practices production of [15O]water for hybrid PET/MR studies. Nucl Med Commun. 2020 Oct;41(10):1100-1105. doi: 10.1097/MNM.0000000000001249. PubMed PMID: 32694283.
Milej D, Shahid M, Abdalmalak A, Rajaram A, Diop M, St Lawrence K. Characterizing dynamic cerebral vascular reactivity using a hybrid system combining time-resolved near-infrared and diffuse correlation spectroscopy. Biomed Opt Express. 2020 Aug 1;11(8):4571-4585. doi: 10.1364/BOE.392113. eCollection 2020 Aug 1. PubMed PMID: 32923065; PubMed Central PMCID: PMC7449704.
Milej D, He L, Abdalmalak A, Baker WB, Anazodo UC, Diop M, Dolui S, Kavuri VC, Pavlosky W, Wang L, Balu R, Detre JA, Amendolia O, Quattrone F, Kofke WA, Yodh AG, St Lawrence K. Quantification of cerebral blood flow in adults by contrast-enhanced near-infrared spectroscopy: Validation against MRI. J Cereb Blood Flow Metab. 2020 Aug;40(8):1672-1684. doi: 10.1177/0271678X19872564. Epub 2019 Sep 9. PubMed PMID: 31500522; PubMed Central PMCID: PMC7370369.
Rajaram A, Yip LCM, Milej D, Suwalski M, Kewin M, Lo M, Carson JJL, Han V, Bhattacharya S, Diop M, de Ribaupierre S, St Lawrence K. Perfusion and Metabolic Neuromonitoring during Ventricular Taps in Infants with Post-Hemorrhagic Ventricular Dilatation. Brain Sci. 2020 Jul 15;10(7). doi: 10.3390/brainsci10070452. PubMed PMID: 32679665; PubMed Central PMCID: PMC7407524.
Abdalmalak A, Milej D, Yip LCM, Khan AR, Diop M, Owen AM, St Lawrence K. Assessing Time-Resolved fNIRS for Brain-Computer Interface Applications of Mental Communication. Front Neurosci. 2020;14:105. doi: 10.3389/fnins.2020.00105. eCollection 2020. PubMed PMID: 32132894; PubMed Central PMCID: PMC7040089.
Ioussoufovitch S, Morrison L, Desjardins L, Hadway J, St Lawrence K, Lee TY, Beier F, Diop M. Quantification of joint blood flow by dynamic contrast-enhanced near-infrared spectroscopy: application to monitoring disease activity in a rat model of rheumatoid arthritis. J Biomed Opt. 2020 Jan;25(1):1-10. doi: 10.1117/1.JBO.25.1.015003. PubMed PMID: 31939225; PubMed Central PMCID: PMC6983648.
Abdalmalak A, Milej D, Cohen DJ, Anazodo U, Ssali T, Diop M, Owen AM, St Lawrence K. Using fMRI to investigate the potential cause of inverse oxygenation reported in fNIRS studies of motor imagery. Neurosci Lett. 2020 Jan 1;714:134607. doi: 10.1016/j.neulet.2019.134607. Epub 2019 Nov 3. PubMed PMID: 31693928.
Kewin M, Rajaram A, Milej D, Abdalmalak A, Morrison L, Diop M, St Lawrence K. Evaluation of hyperspectral NIRS for quantitative measurements of tissue oxygen saturation by comparison to time-resolved NIRS. Biomed Opt Express. 2019 Sep 1;10(9):4789-4802. doi: 10.1364/BOE.10.004789. eCollection 2019 Sep 1. PubMed PMID: 31565525; PubMed Central PMCID: PMC6757477.
Khalid M, Milej D, Rajaram A, Abdalmalak A, Morrison L, Diop M, St Lawrence K. Development of a stand-alone DCS system for monitoring absolute cerebral blood flow. Biomed Opt Express. 2019 Sep 1;10(9):4607-4620. doi: 10.1364/BOE.10.004607. eCollection 2019 Sep 1. PubMed PMID: 31565512; PubMed Central PMCID: PMC6757462.
Busch DR, Balu R, Baker WB, Guo W, He L, Diop M, Milej D, Kavuri V, Amendolia O, St Lawrence K, Yodh AG, Kofke WA. Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy. Neurocrit Care. 2019 Feb;30(1):72-80. doi: 10.1007/s12028-018-0573-1. PubMed PMID: 30030667; PubMed Central PMCID: PMC6528475.
He L, Baker WB, Milej D, Kavuri VC, Mesquita RC, Busch DR, Abramson K, Jiang JY, Diop M, St Lawrence K, Amendolia O, Quattrone F, Balu R, Kofke WA, Yodh AG. Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults. Neurophotonics. 2018 Oct;5(4):045006. doi: 10.1117/1.NPh.5.4.045006. Epub 2018 Nov 23. PubMed PMID: 30480039; PubMed Central PMCID: PMC6251207.
Cavaliere C, Kandeepan S, Aiello M, Ribeiro de Paula D, Marchitelli R, Fiorenza S, Orsini M, Trojano L, Masotta O, St Lawrence K, Loreto V, Chronik BA, Nicolai E, Soddu A, Estraneo A. Multimodal Neuroimaging Approach to Variability of Functional Connectivity in Disorders of Consciousness: A PET/MRI Pilot Study. Front Neurol. 2018;9:861. doi: 10.3389/fneur.2018.00861. eCollection 2018. PubMed PMID: 30405513; PubMed Central PMCID: PMC6200912.
Ssali T, Anazodo UC, Thiessen JD, Prato FS, St Lawrence K. A Noninvasive Method for Quantifying Cerebral Blood Flow by Hybrid PET/MRI. J Nucl Med. 2018 Aug;59(8):1329-1334. doi: 10.2967/jnumed.117.203414. Epub 2018 Mar 9. PubMed PMID: 29523628.
Rajaram A, Bale G, Kewin M, Morrison LB, Tachtsidis I, St Lawrence K, Diop M. Simultaneous monitoring of cerebral perfusion and cytochrome c oxidase by combining broadband near-infrared spectroscopy and diffuse correlation spectroscopy. Biomed Opt Express. 2018 Jun 1;9(6):2588-2603. doi: 10.1364/BOE.9.002588. eCollection 2018 Jun 1. PubMed PMID: 30258675; PubMed Central PMCID: PMC6154190.
Shokouhi M, Clarke C, Morley-Forster P, Moulin DE, Davis KD, St Lawrence K. Structural and Functional Brain Changes at Early and Late Stages of Complex Regional Pain Syndrome. J Pain. 2018 Feb;19(2):146-157. doi: 10.1016/j.jpain.2017.09.007. Epub 2017 Oct 14. PubMed PMID: 29038061.
Bale G, Rajaram A, Kewin M, Morrison L, Bainbridge A, Diop M, St Lawrence K, Tachtsidis I. Broadband NIRS Cerebral Cytochrome-C-Oxidase Response to Anoxia Before and After Hypoxic-Ischaemic Injury in Piglets. Adv Exp Med Biol. 2018;1072:151-156. doi: 10.1007/978-3-319-91287-5_24. PubMed PMID: 30178338; PubMed Central PMCID: PMC6142853.
Anazodo UC, Finger E, Kwan BYM, Pavlosky W, Warrington JC, Günther M, Prato FS, Thiessen JD, St Lawrence KS. Using simultaneous PET/MRI to compare the accuracy of diagnosing frontotemporal dementia by arterial spin labelling MRI and FDG-PET. Neuroimage Clin. 2018;17:405-414. doi: 10.1016/j.nicl.2017.10.033. eCollection 2018. PubMed PMID: 29159053; PubMed Central PMCID: PMC5683801.
Abdalmalak A, Milej D, Norton L, Debicki DB, Gofton T, Diop M, Owen AM, St Lawrence K. Single-session communication with a locked-in patient by functional near-infrared spectroscopy. Neurophotonics. 2017 Oct;4(4):040501. doi: 10.1117/1.NPh.4.4.040501. Epub 2017 Dec 23. PubMed PMID: 29296627; PubMed Central PMCID: PMC5741990.
McLachlan PJ, Kishimoto J, Diop M, Milej D, Lee DSC, de Ribaupierre S, St Lawrence K. Investigating the effects of cerebrospinal fluid removal on cerebral blood flow and oxidative metabolism in infants with post-hemorrhagic ventricular dilatation. Pediatr Res. 2017 Oct;82(4):634-641. doi: 10.1038/pr.2017.131. Epub 2017 Jun 14. PubMed PMID: 28553990.
Abdalmalak A, Milej D, Diop M, Shokouhi M, Naci L, Owen AM, St Lawrence K. Can time-resolved NIRS provide the sensitivity to detect brain activity during motor imagery consistently?. Biomed Opt Express. 2017 Apr 1;8(4):2162-2172. doi: 10.1364/BOE.8.002162. eCollection 2017 Apr 1. PubMed PMID: 28736662; PubMed Central PMCID: PMC5516814.
Ladefoged CN, Law I, Anazodo U, St Lawrence K, Izquierdo-Garcia D, Catana C, Burgos N, Cardoso MJ, Ourselin S, Hutton B, Mérida I, Costes N, Hammers A, Benoit D, Holm S, Juttukonda M, An H, Cabello J, Lukas M, Nekolla S, Ziegler S, Fenchel M, Jakoby B, Casey ME, Benzinger T, Højgaard L, Hansen AE, Andersen FL. A multi-centre evaluation of eleven clinically feasible brain PET/MRI attenuation correction techniques using a large cohort of patients. Neuroimage. 2017 Feb 15;147:346-359. doi: 10.1016/j.neuroimage.2016.12.010. Epub 2016 Dec 14. PubMed PMID: 27988322; PubMed Central PMCID: PMC6818242.
Milej D, Abdalmalak A, McLachlan P, Diop M, Liebert A, St Lawrence K. Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS. Biomed Opt Express. 2016 Nov 1;7(11):4514-4526. doi: 10.1364/BOE.7.004514. eCollection 2016 Nov 1. PubMed PMID: 27895992; PubMed Central PMCID: PMC5119592.
Ssali T, Anazodo UC, Bureau Y, MacIntosh BJ, Günther M, St Lawrence K. Mapping Long-Term Functional Changes in Cerebral Blood Flow by Arterial Spin Labeling. PLoS One. 2016;11(10):e0164112. doi: 10.1371/journal.pone.0164112. eCollection 2016. PubMed PMID: 27706218; PubMed Central PMCID: PMC5051683.
Rajaram A, Ioussoufovitch S, Morrison LB, St Lawrence K, Lee TY, Bureau Y, Diop M. Joint blood flow is more sensitive to inflammatory arthritis than oxyhemoglobin, deoxyhemoglobin, and oxygen saturation. Biomed Opt Express. 2016 Oct 1;7(10):3843-3854. doi: 10.1364/BOE.7.003843. eCollection 2016 Oct 1. PubMed PMID: 27867697; PubMed Central PMCID: PMC5102556.
Verdecchia K, Diop M, Lee A, Morrison LB, Lee TY, St Lawrence K. Assessment of a multi-layered diffuse correlation spectroscopy method for monitoring cerebral blood flow in adults. Biomed Opt Express. 2016 Sep 1;7(9):3659-3674. doi: 10.1364/BOE.7.003659. eCollection 2016 Sep 1. PubMed PMID: 27699127; PubMed Central PMCID: PMC5030039.
Shokouhi M, Davis KD, Moulin DE, Morley-Forster P, Nielson WR, Bureau Y, St Lawrence K. Basal Ganglia Perfusion in Fibromyalgia is Related to Pain Disability and Disease Impact: An Arterial Spin Labeling Study. Clin J Pain. 2016 Jun;32(6):495-505. doi: 10.1097/AJP.0000000000000295. PubMed PMID: 26340652.
Milej D, Abdalmalak A, Janusek D, Diop M, Liebert A, St Lawrence K. Time-resolved subtraction method for measuring optical properties of turbid media. Appl Opt. 2016 Mar 1;55(7):1507-13. doi: 10.1364/AO.55.001507. PubMed PMID: 26974605.
Anazodo UC, Shoemaker JK, Suskin N, Ssali T, Wang DJ, St Lawrence KS. Impaired Cerebrovascular Function in Coronary Artery Disease Patients and Recovery Following Cardiac Rehabilitation. Front Aging Neurosci. 2015;7:224. doi: 10.3389/fnagi.2015.00224. eCollection 2015. PubMed PMID: 26779011; PubMed Central PMCID: PMC4700211.
Anazodo U, Kewin M, Finger E, Thiessen J, Hadway J, Butler J, Pavlosky W, Prato F, Thompson T, St Lawrence K. Preliminary evaluation of MRI-derived input function for quantitative measurement of glucose metabolism in an integrated PET-MRI. EJNMMI Phys. 2015 Dec;2(Suppl 1):A80. doi: 10.1186/2197-7364-2-S1-A80. PubMed PMID: 26956342; PubMed Central PMCID: PMC4798628.
Verdecchia K, Diop M, Morrison LB, Lee TY, St Lawrence K. Assessment of the best flow model to characterize diffuse correlation spectroscopy data acquired directly on the brain. Biomed Opt Express. 2015 Nov 1;6(11):4288-301. doi: 10.1364/BOE.6.004288. eCollection 2015 Nov 1. PubMed PMID: 26600995; PubMed Central PMCID: PMC4646539.
Palomares JA, Tummala S, Wang DJ, Park B, Woo MA, Kang DW, St Lawrence KS, Harper RM, Kumar R. Water Exchange across the Blood-Brain Barrier in Obstructive Sleep Apnea: An MRI Diffusion-Weighted Pseudo-Continuous Arterial Spin Labeling Study. J Neuroimaging. 2015 Nov-Dec;25(6):900-5. doi: 10.1111/jon.12288. Epub 2015 Aug 29. PubMed PMID: 26333175; PubMed Central PMCID: PMC4562408.
Diop M, Kishimoto J, Toronov V, Lee DS, St Lawrence K. Development of a combined broadband near-infrared and diffusion correlation system for monitoring cerebral blood flow and oxidative metabolism in preterm infants. Biomed Opt Express. 2015 Oct 1;6(10):3907-18. doi: 10.1364/BOE.6.003907. eCollection 2015 Oct 1. PubMed PMID: 26504641; PubMed Central PMCID: PMC4605050.
Bakhsheshi MF, Diop M, Morrison LB, St Lawrence K, Lee TY. Coupling of cerebral blood flow and oxygen consumption during hypothermia in newborn piglets as measured by time-resolved near-infrared spectroscopy: a pilot study. Neurophotonics. 2015 Jul;2(3):035006. doi: 10.1117/1.NPh.2.3.035006. Epub 2015 Sep 21. PubMed PMID: 26835481; PubMed Central PMCID: PMC4718069.
Davis KD, Bushnell MC, Iannetti GD, St Lawrence K, Coghill R. Evidence against pain specificity in the dorsal posterior insula. F1000Res. 2015;4:362. doi: 10.12688/f1000research.6833.1. eCollection 2015. PubMed PMID: 26401267; PubMed Central PMCID: PMC4566284.
Tichauer KM, Guthrie M, Hones L, Sinha L, St Lawrence K, Kang-Mieler JJ. Quantitative retinal blood flow mapping from fluorescein videoangiography using tracer kinetic modeling. Opt Lett. 2015 May 15;40(10):2169-72. doi: 10.1364/OL.40.002169. PubMed PMID: 26393691.
Anazodo UC, Thiessen JD, Ssali T, Mandel J, Günther M, Butler J, Pavlosky W, Prato FS, Thompson RT, St Lawrence KS. Feasibility of simultaneous whole-brain imaging on an integrated PET-MRI system using an enhanced 2-point Dixon attenuation correction method. Front Neurosci. 2014;8:434. doi: 10.3389/fnins.2014.00434. eCollection 2014. PubMed PMID: 25601825; PubMed Central PMCID: PMC4283546.
Elliott JT, Diop M, Morrison LB, d'Esterre CD, Lee TY, St Lawrence K. Quantifying cerebral blood flow in an adult pig ischemia model by a depth-resolved dynamic contrast-enhanced optical method. Neuroimage. 2014 Jul 1;94:303-311. doi: 10.1016/j.neuroimage.2014.03.023. Epub 2014 Mar 17. PubMed PMID: 24650601.
Tichauer KM, Diop M, Elliott JT, Samkoe KS, Hasan T, St Lawrence K, Pogue BW. Accounting for pharmacokinetic differences in dual-tracer receptor density imaging. Phys Med Biol. 2014 May 21;59(10):2341-51. doi: 10.1088/0031-9155/59/10/2341. Epub 2014 Apr 17. PubMed PMID: 24743262; PubMed Central PMCID: PMC4039087.
Diop M, Wright E, Toronov V, Lee TY, St Lawrence K. Improved light collection and wavelet de-noising enable quantification of cerebral blood flow and oxygen metabolism by a low-cost, off-the-shelf spectrometer. J Biomed Opt. 2014 May;19(5):057007. doi: 10.1117/1.JBO.19.5.057007. PubMed PMID: 24821577.
Bakhsheshi MF, Diop M, St Lawrence K, Lee TY. Monitoring brain temperature by time-resolved near-infrared spectroscopy: pilot study. J Biomed Opt. 2014 May;19(5):057005. doi: 10.1117/1.JBO.19.5.057005. PubMed PMID: 24817622.
Najiminaini M, Kaminska B, St Lawrence K, Carson JJ. Bolus tracking with nanofilter-based multispectral videography for capturing microvasculature hemodynamics. Sci Rep. 2014 Apr 24;4:4737. doi: 10.1038/srep04737. PubMed PMID: 24759647; PubMed Central PMCID: PMC3998030.
Kishimoto J, de Ribaupierre S, Lee DS, Mehta R, St Lawrence K, Fenster A. 3D ultrasound system to investigate intraventricular hemorrhage in preterm neonates. Phys Med Biol. 2013 Nov 7;58(21):7513-26. doi: 10.1088/0031-9155/58/21/7513. Epub 2013 Oct 8. PubMed PMID: 24099882.
Anazodo UC, Shoemaker JK, Suskin N, St Lawrence KS. An investigation of changes in regional gray matter volume in cardiovascular disease patients, pre and post cardiovascular rehabilitation. Neuroimage Clin. 2013;3:388-95. doi: 10.1016/j.nicl.2013.09.011. eCollection 2013. PubMed PMID: 24273722; PubMed Central PMCID: PMC3814972.
Zuo Z, Wang R, Zhuo Y, Xue R, St Lawrence KS, Wang DJ. Turbo-FLASH based arterial spin labeled perfusion MRI at 7 T. PLoS One. 2013;8(6):e66612. doi: 10.1371/journal.pone.0066612. Print 2013. PubMed PMID: 23818950; PubMed Central PMCID: PMC3688599.
Arora R, Ridha M, Lee DS, Elliott J, Rosenberg HC, Diop M, Lee TY, St Lawrence K. Preservation of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosus. Pediatr Res. 2013 Jun;73(6):713-8. doi: 10.1038/pr.2013.53. Epub 2013 Mar 14. PubMed PMID: 23493169.
St Lawrence K, Verdecchia K, Elliott J, Tichauer K, Diop M, Hoffman L, Lee TY. Kinetic model optimization for characterizing tumour physiology by dynamic contrast-enhanced near-infrared spectroscopy. Phys Med Biol. 2013 Mar 7;58(5):1591-604. doi: 10.1088/0031-9155/58/5/1591. Epub 2013 Feb 15. PubMed PMID: 23417099.
Diop M, St Lawrence K. Improving the depth sensitivity of time-resolved measurements by extracting the distribution of times-of-flight. Biomed Opt Express. 2013 Mar 1;4(3):447-59. doi: 10.1364/BOE.4.000447. Epub 2013 Feb 15. PubMed PMID: 23504445; PubMed Central PMCID: PMC3595088.
Elliott JT, Milej D, Gerega A, Weigl W, Diop M, Morrison LB, Lee TY, Liebert A, St Lawrence K. Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigs. Biomed Opt Express. 2013 Feb 1;4(2):206-18. doi: 10.1364/BOE.4.000206. Epub 2013 Jan 2. PubMed PMID: 23413183; PubMed Central PMCID: PMC3567707.
Verdecchia K, Diop M, Lee TY, St Lawrence K. Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy. J Biomed Opt. 2013 Feb;18(2):27007. doi: 10.1117/1.JBO.18.2.027007. PubMed PMID: 23389684.
Elliott JT, Wright EA, Tichauer KM, Diop M, Morrison LB, Pogue BW, Lee TY, St Lawrence K. Arterial input function of an optical tracer for dynamic contrast enhanced imaging can be determined from pulse oximetry oxygen saturation measurements. Phys Med Biol. 2012 Dec 21;57(24):8285-95. doi: 10.1088/0031-9155/57/24/8285. Epub 2012 Nov 29. PubMed PMID: 23190567.
Yeganeh HZ, Toronov V, Elliott JT, Diop M, Lee TY, St Lawrence K. Broadband continuous-wave technique to measure baseline values and changes in the tissue chromophore concentrations. Biomed Opt Express. 2012 Nov 1;3(11):2761-70. doi: 10.1364/BOE.3.002761. Epub 2012 Oct 9. PubMed PMID: 23162714; PubMed Central PMCID: PMC3493236.
Diop M, St Lawrence K. Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurements. Opt Lett. 2012 Jun 15;37(12):2358-60. doi: 10.1364/OL.37.002358. PubMed PMID: 22739907.
Diop M, Verdecchia K, Lee TY, St Lawrence K. Erratum: Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements: errata. Biomed Opt Express. 2012 Jun 1;3(6):1476-7. doi: 10.1364/BOE.3.001476. Epub 2012 May 23. PubMed PMID: 22741092; PubMed Central PMCID: PMC3370986.
St Lawrence KS, Owen D, Wang DJ. A two-stage approach for measuring vascular water exchange and arterial transit time by diffusion-weighted perfusion MRI. Magn Reson Med. 2012 May;67(5):1275-84. doi: 10.1002/mrm.23104. Epub 2011 Aug 19. PubMed PMID: 21858870; PubMed Central PMCID: PMC4066380.
Owen DG, Clarke CF, Bureau Y, Ganapathy S, Prato FS, St Lawrence KS. Measuring the neural response to continuous intramuscular infusion of hypertonic saline by perfusion MRI. J Magn Reson Imaging. 2012 Mar;35(3):669-77. doi: 10.1002/jmri.22814. Epub 2011 Sep 23. PubMed PMID: 21953816.
Winter JD, St Lawrence KS, Cheng HL. Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI. J Magn Reson Imaging. 2011 Sep;34(3):608-15. doi: 10.1002/jmri.22660. Epub 2011 Jul 14. PubMed PMID: 21761490.
Tichauer KM, Migueis M, Leblond F, Elliott JT, Diop M, St Lawrence K, Lee TY. Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data. Appl Opt. 2011 Jul 20;50(21):3962-72. doi: 10.1364/AO.50.003962. PubMed PMID: 21772380.
Diop M, Verdecchia K, Lee TY, St Lawrence K. Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements. Biomed Opt Express. 2011 Jul 1;2(7):2068-81. doi: 10.1364/BOE.2.002068. Epub 2011 Jun 28. PubMed PMID: 21750781; PubMed Central PMCID: PMC3130590.
Cooper JA, Tichauer KM, Boulton M, Elliott J, Diop M, Arango M, Lee TY, St Lawrence K. Continuous monitoring of absolute cerebral blood flow by near-infrared spectroscopy during global and focal temporary vessel occlusion. J Appl Physiol (1985). 2011 Jun;110(6):1691-8. doi: 10.1152/japplphysiol.01458.2010. Epub 2011 Mar 31. PubMed PMID: 21454747.
Winter JD, Dorner S, Lukovic J, Fisher JA, St Lawrence KS, Kassner A. Noninvasive MRI measures of microstructural and cerebrovascular changes during normal swine brain development. Pediatr Res. 2011 May;69(5 Pt 1):418-24. doi: 10.1203/PDR.0b013e3182110f7e. PubMed PMID: 21258264.
Pucci O, Toronov V, St Lawrence K. Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy. Appl Opt. 2010 Nov 10;49(32):6324-32. doi: 10.1364/AO.49.006324. PubMed PMID: 21068864.
Winter JD, Fierstra J, Dorner S, Fisher JA, St Lawrence KS, Kassner A. Feasibility and precision of cerebral blood flow and cerebrovascular reactivity MRI measurements using a computer-controlled gas delivery system in an anesthetised juvenile animal model. J Magn Reson Imaging. 2010 Nov;32(5):1068-75. doi: 10.1002/jmri.22230. PubMed PMID: 21031510.
Diop M, Tichauer KM, Elliott JT, Migueis M, Lee TY, St Lawrence K. Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets. J Biomed Opt. 2010 Sep-Oct;15(5):057004. doi: 10.1117/1.3488626. PubMed PMID: 21054120.
Tichauer KM, Elliott JT, Hadway JA, Lee DS, Lee TY, St Lawrence K. Using near-infrared spectroscopy to measure cerebral metabolic rate of oxygen under multiple levels of arterial oxygenation in piglets. J Appl Physiol (1985). 2010 Sep;109(3):878-85. doi: 10.1152/japplphysiol.01432.2009. Epub 2010 Jul 8. PubMed PMID: 20616228.
Elliott JT, Diop M, Tichauer KM, Lee TY, St Lawrence K. Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy. J Biomed Opt. 2010 May-Jun;15(3):037014. doi: 10.1117/1.3449579. PubMed PMID: 20615043.
Wu WC, St Lawrence KS, Licht DJ, Wang DJ. Quantification issues in arterial spin labeling perfusion magnetic resonance imaging. Top Magn Reson Imaging. 2010 Apr;21(2):65-73. doi: 10.1097/RMR.0b013e31821e570a. Review. PubMed PMID: 21613872.
Owen DG, Clarke CF, Ganapathy S, Prato FS, St Lawrence KS. Using perfusion MRI to measure the dynamic changes in neural activation associated with tonic muscular pain. Pain. 2010 Mar;148(3):375-386. doi: 10.1016/j.pain.2009.10.003. Epub 2009 Nov 14. PubMed PMID: 19914778.
Diop M, Elliott JT, Tichauer KM, Lee TY, St Lawrence K. A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets. Rev Sci Instrum. 2009 May;80(5):054302. doi: 10.1063/1.3123347. PubMed PMID: 19485521.
Tichauer KM, Elliott JT, Hadway JA, Lee TY, St Lawrence K. Cerebral metabolic rate of oxygen and amplitude-integrated electroencephalography during early reperfusion after hypoxia-ischemia in piglets. J Appl Physiol (1985). 2009 May;106(5):1506-12. doi: 10.1152/japplphysiol.91156.2008. Epub 2009 Mar 19. PubMed PMID: 19299571.
Tichauer KM, Wong DY, Hadway JA, Rylett RJ, Lee TY, St Lawrence K. Assessing the severity of perinatal hypoxia-ischemia in piglets using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen. Pediatr Res. 2009 Mar;65(3):301-6. doi: 10.1203/PDR.0b013e318194faa6. PubMed PMID: 19033882.
Winter JD, Tichauer KM, Gelman N, Thompson RT, Lee TY, St Lawrence K. Changes in cerebral oxygen consumption and high-energy phosphates during early recovery in hypoxic-ischemic piglets: a combined near-infrared and magnetic resonance spectroscopy study. Pediatr Res. 2009 Feb;65(2):181-7. doi: 10.1203/PDR.0b013e31818f06fb. PubMed PMID: 18852691.
Koziak AM, Winter J, Lee TY, Thompson RT, St Lawrence KS. Validation study of a pulsed arterial spin labeling technique by comparison to perfusion computed tomography. Magn Reson Imaging. 2008 May;26(4):543-53. doi: 10.1016/j.mri.2007.10.005. Epub 2007 Dec 11. PubMed PMID: 18063336.
Owen DG, Bureau Y, Thomas AW, Prato FS, St Lawrence KS. Quantification of pain-induced changes in cerebral blood flow by perfusion MRI. Pain. 2008 May;136(1-2):85-96. doi: 10.1016/j.pain.2007.06.021. Epub 2007 Aug 22. PubMed PMID: 17716820.
Wang J, Fernández-Seara MA, Wang S, St Lawrence KS. When perfusion meets diffusion: in vivo measurement of water permeability in human brain. J Cereb Blood Flow Metab. 2007 Apr;27(4):839-49. doi: 10.1038/sj.jcbfm.9600398. Epub 2006 Sep 13. PubMed PMID: 16969383.
Tichauer KM, Hadway JA, Lee TY, St Lawrence K. Measurement of cerebral oxidative metabolism with near-infrared spectroscopy: a validation study. J Cereb Blood Flow Metab. 2006 May;26(5):722-30. doi: 10.1038/sj.jcbfm.9600230. PubMed PMID: 16192991.
Tichauer KM, Brown DW, Hadway J, Lee TY, St Lawrence K. Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets. J Appl Physiol (1985). 2006 Mar;100(3):850-7. doi: 10.1152/japplphysiol.00830.2005. Epub 2005 Nov 17. PubMed PMID: 16293704.
St Lawrence KS, Frank JA, Bandettini PA, Ye FQ. Noise reduction in multi-slice arterial spin tagging imaging. Magn Reson Med. 2005 Mar;53(3):735-8. doi: 10.1002/mrm.20396. PubMed PMID: 15723412.
St Lawrence KS, Wang J. Effects of the apparent transverse relaxation time on cerebral blood flow measurements obtained by arterial spin labeling. Magn Reson Med. 2005 Feb;53(2):425-33. doi: 10.1002/mrm.20364. PubMed PMID: 15678532.
St Lawrence KS, Ye FQ, Lewis BK, Frank JA, McLaughlin AC. Measuring the effects of indomethacin on changes in cerebral oxidative metabolism and cerebral blood flow during sensorimotor activation. Magn Reson Med. 2003 Jul;50(1):99-106. doi: 10.1002/mrm.10502. PubMed PMID: 12815684.
St Lawrence KS, Ye FQ, Lewis BK, Weinberger DR, Frank JA, McLaughlin AC. Effects of indomethacin on cerebral blood flow at rest and during hypercapnia: an arterial spin tagging study in humans. J Magn Reson Imaging. 2002 Jun;15(6):628-35. doi: 10.1002/jmri.10111. PubMed PMID: 12112512.
Barbier EL, St Lawrence KS, Grillon E, Koretsky AP, Décorps M. A model of blood-brain barrier permeability to water: accounting for blood inflow and longitudinal relaxation effects. Magn Reson Med. 2002 Jun;47(6):1100-9. doi: 10.1002/mrm.10158. PubMed PMID: 12111956.
St Lawrence KS, Frank JA, McLaughlin AC. Effect of restricted water exchange on cerebral blood flow values calculated with arterial spin tagging: a theoretical investigation. Magn Reson Med. 2000 Sep;44(3):440-9. doi: 10.1002/1522-2594(200009)44:3<440::aid-mrm15>3.0.co;2-6. PubMed PMID: 10975897.
St Lawrence KS, Lee TY. An adiabatic approximation to the tissue homogeneity model for water exchange in the brain: II. Experimental validation. J Cereb Blood Flow Metab. 1998 Dec;18(12):1378-85. doi: 10.1097/00004647-199812000-00012. PubMed PMID: 9850150.
St Lawrence KS, Lee TY. An adiabatic approximation to the tissue homogeneity model for water exchange in the brain: I. Theoretical derivation. J Cereb Blood Flow Metab. 1998 Dec;18(12):1365-77. doi: 10.1097/00004647-199812000-00011. PubMed PMID: 9850149.
St Lawrence K, Lee TY, Henkelman M. Spatial localization combining projection presaturation with a two-dimensional excitation pulse. Magn Reson Med. 1998 Dec;40(6):944-7. doi: 10.1002/mrm.1910400623. PubMed PMID: 9840842.
Bews J, St Lawrence K, Dunscombe P, McClarty B, Kroeker M. A simplified method for measuring cerebral blood flow with xenon-enhanced computed tomography. Clin Phys Physiol Meas. 1991 Aug;12(3):279-87. doi: 10.1088/0143-0815/12/3/009. PubMed PMID: 1934915.